„Towards immunomodulatory and anti(lymph)angiogenic therapies for age-related blinding eye diseases”
Research
Program
Healthy eyes are a prerequisite for good vision. Ophthalmology is the medical discipline responsible for preserving and restoring eye function, which is generally done very successfully. There are, however, eye diseases with poorly understood causes and insufficient therapies. As most of these under-addressable eye diseases are age-associated, the prevalence will increase due to our aging society. Beyond significant loss in quality of life of individuals, leaving these diseases under-investigated will affect and burden society, increasing the need for a specialized research center.
Visionary Ocular Innovation
Our CRC has a unique position since there is currently no other international center that focusses on the role of lymphatic/blood vessels and immune cells as the cause of, and new therapeutic target in, age-associated ocular diseases. We therefore propose a new CRC 1607 gathered around the perspective that within 12 years a significant progress in disease understanding and translation into clinical care can be achieved with the following objectives:
- Unravel the disease mechanisms of age-associated eye diseases with a special focus on the role of aberrant cellular immunity/inflammation and (lymph)angiogenesis,
- To develop innovative new treatment concepts based thereon and,
- To transfer at least 25% of projects to early pilot patient data in the last funding period.
Integrative Vision Research Expansion
Tremendous progress has been made in (lymph)angiogenesis and cellular immunity/inflammation research recently. Not least through our research group FOR 2240. Now is the time to transfer this to specific ocular diseases. We included non-ophthalmic experts in the fields of (lymph)angiogenesis and inflammation research as well as image analysis and artificial intelligence into our CRC, thereby enabling (i) a transfer of external expertise to ophthalmological diseases and (ii) better use of the eye as an easily accessible model system to unravel disease mechanisms relevant even beyond ophthalmology.
This will help us to reach our overarching goal: the development of new therapeutic concepts in this area of high unmet need to alleviate the individual and societal burden of age-associated vision loss.
see whats
more
Projects
Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam erat, sed diam voluptua. At vero eos et accusam et justo duo dolores et ea rebum. Stet clita kasd gubergren, no sea takimata sanctus est Lorem ipsum dolor sit amet. Lorem ipsum dolor sit amet, consetetur sadipscing elitr, sed diam nonumy eirmod tempor invidunt ut labore et dolore magna aliquyam