Dr. med. Hanhan Liu

CRC 1607 | Dr. med. Hanhan Liu

Department of Ophthalmology
University Hospital Cologne
Kerpener Str. 62
50937 Cologne, Germany
+49 221 478 96996


Project leader

Scientific career

Since 2022 Editorship Medicine Advances

2020-2021 Postdoctoral researcher, Department of Ophthalmology, Faculty of Medicine and University Hospital of Cologne, University of Cologne

2021-today Clinician Scientist in the Cologne Clinician Scientist Program (CCSP), 50%

research position, 50% clinical training

2020 Doctorate, Subject: The protective role and underlying mechanism of hydrogen sulfide against glaucomatous injuries in vitro and in vivo

Prizes and honors

2018 Glaucoma research award, German Ophthalmological Society (DOG)

2020 Paper of the month, World Glaucoma Association (WGA)

2021 Science award, Association of Rheinish-Westphalian ophthalmologists (RWA)

Selected publications

  1. Liu H, Bell K, Herrmann A, Arnhold S, Mercieca K, Prokosch V, et al. (2022) Crystallins Play a Crucial Role in Glaucoma and Promote Neuronal Cell Survival in an In Vitro Model Through Modulating Muller Cell Secretion. Investigative ophthalmology & visual science 2022, 63, 3,
  2. Liu H, Tang J, Chu H, Li Q, Prokosch V, Cui H, et al. (2022) Aqueous Humor Cytokine Response in the Contralateral Eye after First-Eye Cataract Surgery in Patients with Primary Angle-Closure Glaucoma, High Myopia or Type 2 Diabetes Mellitus. Frontiers in bioscience 2022, 27, 222
  3. Wang M, Liu H, Xia N, Li H, van Beers T, Gericke A, Prokosch V. (2022) Intraocular Pressure-Induced Endothelial Dysfunction of Retinal Blood Vessels Is Persistent but Does Not Trigger Retinal Ganglion Cell Loss. Antioxidants 2022, 11
  4. Liu H, Perumal N, Manicam C, Mercieca K, Prokosch V. (2020) Proteomics reveals the potential protective mechanism of hydrogen sulfide on retinal ganglion cells in an ischemia/reperfusion injury animal model. Pharmaceuticals (Basel) 2020, 13
  5. Liu H, Anders F, Funke S, Mercieca K, Grus F, Prokosch V. (2020) Proteome alterations in aqueous humour of primary open angle glaucoma patients. International journal of ophthalmology 2020, 13, 176-179
  6. Brockhaus K, Melkonyan H, Prokosch V, Liu H, Thanos S. (2020) Alterations in Tight- and Adherens-Junction Proteins Related to Glaucoma Mimicked in the Organotypically Cultivated Mouse Retina Under Elevated Pressure. Investigative Ophthalmology & Visual Science 2020. 61(3): p. 46
  7. Liu H, Mercieca K, Prokosch V. (2020) Mitochondrial markers in aging and primary open-angle glaucoma. (Paper of the month- World Glaucoma Association, April 2020) Journal of glaucoma 2020, 29, 295-303
  8. Prokosch V, Brockhaus K, Anders F, Liu H, Mercieca K, Gericke A, Melkonyan H, Thanos S. (2019) Elevated intraocular pressure induces neuron-specific beta-III-tubulin expression in non-neuronal vascular cells. Acta ophthalmologica 2019, 10.1111/aos.14333
  9. Lauzi J, Anders F, Liu H, Pfeiffer N, Grus F, Thanos S, Arnhold S, Prokosch V. (2019) Neuroprotective and neuroregenerative effects of CRMP-5 on retinal ganglion cells in an experimental in vivo and in vitro model of glaucoma. PloS one 2019, 14, e0207190
  10. Liu H, Anders F, Thanos S, Mann C, Liu A, Grus FH, Pfeiffer N, Prokosch V. (2017) Hydrogen sulfide protects retinal ganglion cells against glaucomatous injury in vitro and in vivo. Investigative ophthalmology & visual science 2017, 58, 5129-5141