Prof. Dr. med. Dr. nat. med. Adele Rüger

CRC 1607 | Prof. Dr. med. Dr. nat. med. Adele Rüger

Department of Neurology
University Hospital of Cologne
Kerpener Str. 62, 50931 Cologne, Germany
+49 478 87803


Project leader

Scientific career

Since 2019 Professorship (apl), Faculty of Medicine, University of Cologne

Since 2013 Consultant Neurologist (Oberärztin): Dept. of Neurology, Univ. Hospital of Cologne

2011 Board exams as Consulting Neurologist (Fachärztin)

2007-2013 Neurological residency: Dpt. of Neurology, Univ. Hosp. Cologne

2005-2007 2nd postdoctoral fellowship: NINDS, Bethesda, USA (supervisor: Prof. R.D.G. McKay)

2004-2005 1st postdoctoral fellowship: MPI for Neurological Research, Cologne (supervisor: Prof. A.H. Jacobs)

2003-2004 Neurological residency: Dept. of Neurology, Univ. Hospital of Cologne

Prizes and honors

Nominated for the federal award in the initiative ‘Germany – Land of Ideas’, founded by the federal government and the Federation of German Industries, 2011
Best Publication of 2010, awarded by the Medical Faculty of the Univ. of Cologne

Selected publications

  1. Blaschke S, Hensel L, Minassian A, Vlachakis S, Tscherpel C, Vay SU, Rabenstein M, Schroeter M, Fink GR, Hoehn M, Grefkes C, Rueger MA (2021). Translating functional connectivity after stroke: fMRI detects comparable network changes in mice and humans. Stroke; 52(9): 2948-2960.
  2. Schlusche AK, Vay SU, Kleinenkuhnen N, Sandke S, Campos-Martin R, Florio M, Huttner W, Tresch A, Roeper J, Rueger MA, Jakovcevski I, Stockebrand M, Isbrandt D (2021). Developmental HCN channelopathy results in decreased neural progenitor proliferation and microcephaly in mice. Proc Natl Acad Sci USA; 118(35): e2009393118.
  3. Blaschke SJ, Demir S, König A, Abraham JA, Vay SU, Rabenstein M, Olschewski DN, Hoffmann C, Hoffmann M, Hersch N, Merkel R, Hoffmann B, Schroeter M, Fink GR, Rueger MA (2020) Substrate Elasticity Exerts Functional Effects on Primary Microglia. Front. Cell. Neurosci; 14: 590500.
  4. Vay SU, Flitsch LJ, Rabenstein M, Monière H, Jakovcevski I, Andjus P, Bijelic D, Blaschke S, Walter HL, Fink GR, Schroeter M, Rueger MA (2020) The impact of hyperpolarization-activated cyclic nucleotide-gated (HCN) and voltage-gated potassium KCNQ/Kv7 channels on primary microglia function. J Neuroinflammation; 17(1): 100.
  5. Rabenstein M, Vay SU, Blaschke S, Walter HL, Ladwig A, Fink GR, Rueger MA*, Schroeter M* (2020) Crosstalk between stressed brain cells: direct and indirect effects of ischemia and aglycemia on microglia. J Neuroinflammation; 17(1): 33.
  6. Blaschke S, Vay SU, Pallast N, Rabenstein M, Abraham JA, Linnartz C, Hoffmann M, Hersch N, Merkel R, Hoffmann B, Fink GR, Rueger MA (2019) Substrate elasticity induces quiescence and promotes neurogenesis of primary neural stem cells-A biophysical in vitro model of the physiological cerebral milieu. J Tissue Eng Regen Med; 13(6): 960-972.
  7. Vay SU, Flitsch LJ, Rabenstein M, Rogall R, Blaschke S, Kleinhaus J, Reinert N, Bach A, Fink GR, Schroeter M, Rueger MA (2018). The plasticity of primary microglia and their multifaceted effects on endogenous neural stem cells in vitro and in vivo. J Neuroinflammation; 15(1): 226.
  8. Braun R, Klein R, Walter HL, Ohren M; Freudenmacher L, Getachew K, Ladwig A, Luelling J, Neumaier B, Endepols H, Graf R, Hoehn M, Fink GR, Schroeter M, Rueger MA (2016). Transcranial direct current stimulation accelerates recovery of function, induces neurogenesis and recruits oligodendrocyte precursors in a rat model of stroke. Exp Neurol; 279: 127-136.
  9. Rueger MA, Backes H, Walberer M, Neumaier B, Ullrich R, Simard ML, Emig B, Fink GR, Hoehn M, Graf R, Schroeter M (2010). Non-invasive imaging of endogenous neural stem cell mobilization in vivo using Positron Emission Tomography. J Neurosci; 30(18):6454-6460.
  10. Androutsellis-Theotokis A, Leker RR, Soldner F, Hoeppner DJ, Ravin R, Poser SW, Rueger MA, Bae SK, Kittappa R, McKay RD (2006). Notch signalling regulates stem cell numbers in vitro and in vivo. Nature; 442(7104): 823-826.