Prof. Dr. med. Dr. phil. Ludwig M. Heindl

CRC 1607 | Prof. Dr. med. Dr. phil. Ludwig M. Heindl

Department of Ophthalmology
University of Cologne
Kerperner Str. 62
50937 Cologne, Germany
Tel. (+49) 221 4784 300
Fax. (+49) 221 4785 094
Email: ludwig.heindl@uk-koeln.de

Projects:

Project leader

C03

Scientific career

1998-2006 Study of Medicine at the Universities of Erlangen-Nuremberg/Germany and Vienna/Austria, Medical Licensure

2006 Doctorate degree (Dr. med.), (magna cum laude) at the University of Erlangen-Nuremberg

2006-2010 Residency, Department of Ophthalmology, University of Erlangen-Nuremberg

2006-2010 Training in Ophthalmic Pathology, Prof. Dr. G.O.H. Naumann, University of Erlangen-Nuremberg

2011 Specialist Certification in Ophthalmology

2011- Consultant in General Ophthalmology, Ophthalmic Oncology and Ophthalmic Pathology, Department of Ophthalmology, University of Cologne

2012 Habilitation and Venia Legendi at the Faculty of Medicine, University of Cologne

2013- Head of Ophthalmic Oncology, Ophthalmic Plastic and Reconstructive Service, Department of Ophthalmology, University of Cologne

2015- Principal Investigator of Project 4 “Tumor-associated lymphangiogenesis and its inhibition as a novel therapeutic strategy in conjunctival melanomas” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne

2016- University Professor (W2) for Ophthalmic Oncology, University of Cologne

2016- Member of the Executive Board, Center for Integrated Oncology (CIO) Cologne-Bonn

2018- Principal Investigator of Project P4 “The role of midkine in tumor-associated lymphangiogenesis and metastasis of ocular malignant melanoma” in the DFG Research Unit FOR 2240 “Angiogenesis, Lymphangiogenesis and Cellular Immunity in Inflammatory Diseases of the Eye” at the Department of Ophthalmology, University of Cologne

2020 Master of Science (M.Sc.) “with distinction” at Paracelsus Medical Private University Salzburg, Austria

2021 Doctorate degree (Dr. phil./Ph.D.) “with distinction” at Paracelsus Medical Private University Salzburg, Austria

Prizes and honors

2007 Junior Award – European Society of Ophthalmic Plastic and Reconstructive Surgery (ESOPRS)

2008 Best Paper Award – American Academy of Ophthalmology (AAO)

2010 Senator-Hermann-Wacker-Award – German Ophthalmological Society (DOG)

2011 Best Young Investigator Award – European Ophthalmic Oncology Group (OOG)

2011 Editor’s Choice Award – American Academy of Ophthalmology (AAO)

2012 Novartis Travel Fellowship – International Society for Eye Research (ISER)

2012 Ludwig von Sallmann Clinician-Scientist Award – Association for Research in Vision and Ophthalmology (ARVO)

2014 and 2017 Best Reviewer Award – Klinische Monatsblätter für Augenheilkunde

2017 Leonhard Klein Award – German Ophthalmological Society (DOG)

2017 Erwin Niehaus Prize for Ophthalmology (Erwin Niehaus Foundation)

2021 Leonhard Klein Award – German Ophthalmological Society (DOG)

2022 Honorary Professor (Prof. h. c.), Zhejiang University, School of Medicine in Hangzhou, China

Selected publications

  1. Karg MM, John L, Refaian N, Buettner C, Rottmar T, Sommer J, Bock B, Resheq YJ, Ksander BR, Heindl LM, Mackensen A, Bosch JJ. Midkine promotes metastasis and therapeutic resistance via mTOR/RPS6 in uveal melanoma. Mol Cancer Res. 2022;20:1320-1336.
  2. Rokohl AC, Trester M, Guo Y, Adler W, Jaeger VK, Loreck N, Mor JM, Pine KR, Heindl LM. Dry anophthalmic socket syndrome – standardized clinical evaluation of symptoms and signs. Ocul Surf 2020;18:453-459.
  3. Luers JC, Rokohl AC, Loreck N, Wawer Matos PA, Augustin M, Dewald F, Klein F, Lehmann C, Heindl LM. Olfactory and gustatory dysfunction in coronavirus disease 19 (COVID-19). Clin Infect Dis 2020.
  4. Schlereth SL, Karlstetter M, Hos D, Matthaei M, Cursiefen C, Heindl LM. Detection of Pro- and Antiangiogenic Factors in the Human Sclera. Curr Eye Res 2019;44:172-84
  5. Kittler JM, Sommer J, Fischer A, Britting S, Karg MM, Bock B, Atreya I, Heindl LM, Mackensen A, Bosch JJ. Characterization of CD4+ T cells primed and boosted by MHCII primary uveal melanoma cell-based vaccines. Oncotarget 2019;10:1812-28
  6. Grajewski RS, Bosch JJ, Bruns H, Cursiefen C, Heindl LM. The Trojan Horse Tale Revisited: An Eye on Metastatic Spread of Carcinoma Cells. Cancer Immunol Res. 2016; 4: 92-4.
  7. Heindl LM, Koch KR, Hermann MM, Merkelbach-Bruse S, Schultheis AM, Wagener S, Büttner R, Mauch C, Schuler-Thurner B, Schuler G, Cursiefen C. Block Excision of Iridociliary Tumors Enables Molecular Profiling and Immune Vaccination. Ophthalmology 2017; 124: 268-270.
  8. Yan S, Golumba-Nagy V, Kotschenreuther K, Thiele J, Refaian N, Shuya D, Gloyer L, Dittrich-Salamon M, Meyer A, Heindl LM, Kofler DM. Membrane-bound IL-6R is upregulated on Th17 cells and inhibits Treg cell migration by regulating post-translational modification of VASP in autoimmune arthritis. Cell Mol Life Sci. 2021
  9. Bosch JJ, Heindl LM. [Novel Adjuvant Therapy for Ocular Melanoma]. Klin Monbl Augenheilkd. 2017; 234(5):670-673.
  10. Schlereth SL, Iden S, Mescher M, Ksander BR, Bosch JJ, Cursiefen C, Heindl LM. A Novel Model of Metastatic Conjunctival Melanoma in Immune-Competent Mice. Invest Ophthalmol Vis Sci. 2015;56(10):5965-73.