Prof. Dr. med. Jonathan Jantsch

Institut für Medizinische Mikrobiologie, Immunologie und Hygiene
University of Cologne and University Hospital Cologne
Goldenfelsstr. 19-21
50935 Cologne, Germany
Tel. +49 (0)221 32000
Email: Jonathan.Jantsch@uk-koeln.de

Projects:

Project leader

B02

Scientific career

04/2022 – today W3 Professor and Director, Institute of Medical Microbiology, Immunology and Hygiene, University of Cologne and University Hospital of Cologne

Since 2019 Member Editorial Board, Scientific Reports

01/2017 – 03/2022 W2 Associate Professor and Head of Clinical Bacteriology, Institute of Clinical Microbiology and Hygiene, Universitätsklinikum Regensburg

Since 2018 Member Editorial Board, Medical Microbiology and Immunology

2017 Guest Editor, Special Issue “Pflügers Archiv – European Journal of Physiology” on “Macrophages in tissue homeostasis” together with Prof. Kurts and Prof. Schultze (University of Bonn)

Since 2017 Elected Member of the Council of European Macrophage and Dendritic Cell Society

Since 2017 Elected Deputy Speaker of the Fachgruppe Infection Immunology of the Deutsche Gesellschaft für Hygiene and Mikrobiologie and the Deutsche Gesellschaft für Immunologie

06/2014 – 12/2016 W2 Associate Professor and Deputy Head of Clinical Bacteriology, Institute of Clinical Microbiology and Hygiene, Universitätsklinikum Regensburg

2014 Board Certification „Microbiology, Virology and Epidemiology of Infectious Diseases“

2014 Habilitation, Subject: Medical Microbiology and Immunology

01/2010 – 05/2014 Research Group Leader and Resident, Mikrobiologisches Institut – Clinical Microbiology, Immunology and Hygiene, Universitätsklinikum Erlangen and FAU Erlangen-Nürnberg

07/2005 – 06/2008 Resident physician and scientific assistant, Universitätsklinikum Erlangen and FAU Erlangen-Nürnberg

Prizes and honors

2012 Young Investigator Award, German Society of Hygiene and Microbiology

2006 Staedtler-Thesis Award, Medical Faculty, University of Erlangen-Nürnberg

1998-2004 Scholarship for the Highly Talented Students, Bavarian State

Selected publications

  1. Jobin, K., Müller, D. N., Jantsch, J.*, and Kurts, C.* (2021). Sodium and ist manifold impact on our immune system. Trends Immunol, 42(6):469-479 (*shared senior authorship)
  2. Neubert P, Homann A, Wendelborn D, Bär AL, Krampert L, Trum M, Schröder A, Ebner S, Weichselbaum A, Schatz V, Linz P, Veelken R, Schulte-Schrepping J, Aschenbrenner AC, Quast T, Kurts C, Geisberger S, Kunzelmann K, Hammer K, Binger KJ, Titze J, Müller DN, Kolanus W, Schultze JL, Wagner S and Jantsch J. (2020). NCX1 represents an ionic Na+ sensing mechanism in macrophages. PLOS Biology, 18:6. doi: 10.1371/journal.pbio.3000722.1
  3. Schröder A, Neubert P, Titze J, Bozec A, Neuhofer W, Proff P, Kirschneck C and Jantsch J. (2019). Osteoprotective action of low-salt diet requires myeloid cell-derived NFAT5. JCI Insight, 4: 23. Doi: 10.1172/jci.insight.127868.
  4. Neubert P, Weichselbaum A, Reitinger C, Schatz V, Schröder A, Ferdinand J, Simon M, Bär AL, Brochhausen C, Gerlach RG, Tomiuk S, Hammer K, Wagner S, van Zandbergen G, Binger KJ, Müller DN, Kitada K, Clatworthy MR, Kurts C, Titze J, Abdullah Z and Jantsch, J. (2019). HIF1A and NFAT5 coordinate Na+-boosted antibacterial defense via enhanced autophagy and autolysosomal targeting. Autophagy, 2019: 1899-1916
  5. Hayek I, Fischer F, Schulze-Lührmann J, Dettmer K, Sobotta K, Schatz V, Kohl L, Boden K, Lang R, Oefner PJ, Wirtz S, Jantsch J* and Lührmann A* (2019). Limitation of TCA-cycle intermediates represents an oxygen-independent nutritional antibacterial effector mechanism of macrophages. Cell Reports 26: 3502-3510 (*shared senior authorship).
  6. Schatz V, Strüssmann Y, Mahnke A, Schley G, Waldner M, Ritter U, Wild J, Willam C, Dehne N, Brüne B, McNiff J M, Colegio O R, Bogdan C and Jantsch J. (2016). Myeloid cell-derived HIF-1alpha promotes control of Leishmania major. J Immunol 197: 4034-41.
  7. Jantsch J*, Schatz V, Friedrich D, Schroder A, Kopp C, Siegert I, Maronna A, Wendelborn D, Linz P, Binger K J, Gebhardt M, Heinig M, Neubert P, Fischer F, Teufel S, David J P, Neufert C, Cavallaro A, Rakova N, Kuper C, Beck F X, Neuhofer W, Muller D N, Schuler G, Uder M, Bogdan C, Luft F C and Titze J. (2015). Cutaneous Na+ storage strengthens the antimicrobial barrier function of the skin and boosts macrophage-driven host defense. Cell Metab 21: 493-501. *(corresponding author)
  8. Jennewein J, Matuszak J, Walter S, Felmy B, Gendera K, Schatz V, Nowottny M, Liebsch G, Hensel M, Hardt W D, Gerlach R G and Jantsch J. (2015). Low-oxygen tensions found in Salmonella-infected gut tissue boost Salmonella replication in macrophages by impairing antimicrobial activity and augmenting Salmonella virulence. Cell Microbiol 17: 1833-47.
  9. Siegert I, Schödel J, Nairz M, Schatz V, Dettmer K, Dick C, Kalucka J, Franke K, Ehrenschwender M, Schley G, Beneke A, Sutter J, Moll M, Hellerbrand C, Wielockx B, Katschinski D M, Lang R, Galy B, Hentze M W, Koivunen P, Oefner P J, Bogdan C, Weiss G, Willam C and Jantsch J. (2015). Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1alpha upon LPS activation in the presence of ample oxygen. Cell Reports 13: 2048-55.
  10. Mahnke A, Meier R J, Schatz V, Hofmann J, Castiglione K, Schleicher U, Wolfbeis O S, Bogdan C and Jantsch J. (2014). Hypoxia in Leishmania major skin lesions impairs the NO-dependent leishmanicidal activity of macrophages. J Invest Dermatol 134: 2339-46.