Prof. Dr. rer.-nat. Manolis Pasparakis

CRC 1607 | Prof. Manolis Pasparakis

Institute for Genetics,
The Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD)
University of Cologne
Joseph-Stelzmann Str. 26
50931 Cologne, Germany
+49 221 478 84349
Email: pasparakis@uni-koeln.de

Projects:

Project leader

B01

Scientific career

Since 2020 Speaker, CRC1403 on “Cell Death in Immunity, Inflammation and Disease”

2012 – 2014 Chair, LS4 Review Panel for ERC Consolidator Grants

2009 – 2016 Member of the Committee for Good Scientific Practice, University of Cologne

2009 – 2012 Member, LS4 Review Panel for ERC Starting Grants

Since 2008 Member of the Academic Advisory Board, University of Cologne

2008 Elected Member of the European Molecular Biology Organisation (EMBO)

2008 Advisory Board, Department for Molecular Biomedical Research, VIB (Gent)

Since 2007 Executive Board Member and Research Area Leader, Excellence Cluster CECAD#

2005 – present W3 full professorship, Institute for Genetics, University of Cologne

2005 Chair, External evaluation board, Department for Molecular Biomedical Research, VIB (Gent, Belgium)

2002 – 2005 Independent Group Leader, Mouse Biology Unit, European Molecular Biology Laboratory (EMBL), Monterotondo (Rome), Italy

2000-2001 The Leukemia & Lymphoma Society, Special Postdoctoral Fellowship

1997 – 2001 Postdoctoral fellow, Department of Immunology, Institute for Genetics, University of Cologne (Group of Professor Dr. Klaus Rajewsky)

1997-1999 EMBO long-term postdoctoral fellowship

Prizes and honors

2018 ERC Advanced Investigator Grant Award (project NECROPTOSIS)

2013 ERC Advanced Investigator Grant Award (project EPINFLAM)

Selected publications

  1. Jiao H, Wachsmuth L, Wolf S, Lohmann J, Nagata M, Kaya GG, Oikonomou N, Kondylis V, Rogg M, Diebold M, Troder SE, Zevnik B, Prinz M, Schell C, Young GR, Kassiotis G, Pasparakis M (2022) ADAR1 averts fatal type I interferon induction by ZBP1. Nature 607: 776-783
  2. Schwarzer R, Jiao H, Wachsmuth L, Tresch A, Pasparakis M (2020) FADD and Caspase-8 Regulate Gut Homeostasis and Inflammation by Controlling MLKL- and GSDMD-Mediated Death of Intestinal Epithelial Cells. Immunity 52: 978-993 e6
  3. Jiao H, Wachsmuth L, Kumari S, Schwarzer R, Lin J, Eren RO, Fisher A, Lane R, Young GR, Kassiotis G, Kaiser WJ, Pasparakis M (2020) Z-nucleic-acid sensing triggers ZBP1-dependent necroptosis and inflammation. Nature 580: 391-395
  4. Polykratis A, Martens A, Eren RO, Shirasaki Y, Yamagishi M, Yamaguchi Y, Uemura S, Miura M, Holzmann B, Kollias G, Armaka M, van Loo G, Pasparakis M (2019) A20 prevents inflammasome-dependent arthritis by inhibiting macrophage necroptosis through its ZnF7 ubiquitin-binding domain. Nat Cell Biol 21: 731-742
  5. Vlantis K, Wullaert A, Polykratis A, Kondylis V, Dannappel M, Schwarzer R, Welz P, Corona T, Walczak H, Weih F, Klein U, Kelliher M, Pasparakis M (2016) NEMO Prevents RIP Kinase 1-Mediated Epithelial Cell Death and Chronic Intestinal Inflammation by NF-kappaB-Dependent and -Independent Functions. Immunity 44: 553-567
  6. Lin J, Kumari S, Kim C, Van TM, Wachsmuth L, Polykratis A, Pasparakis M (2016) RIPK1 counteracts ZBP1-mediated necroptosis to inhibit inflammation. Nature 540: 124-128
  7. Kondylis V, Polykratis A, Ehlken H, Ochoa-Callejero L, Straub BK, Krishna-Subramanian S, Van TM, Curth HM, Heise N, Weih F, Klein U, Schirmacher P, Kelliher M, Pasparakis M (2015) NEMO Prevents Steatohepatitis and Hepatocellular Carcinoma by Inhibiting RIPK1 Kinase Activity-Mediated Hepatocyte Apoptosis. Cancer Cell 28: 582-598
  8. Dannappel M, Vlantis K, Kumari S, Polykratis A, Kim C, Wachsmuth L, Eftychi C, Lin J, Corona T, Hermance N, Zelic M, Kirsch P, Basic M, Bleich A, Kelliher M, Pasparakis M (2014) RIPK1 maintains epithelial homeostasis by inhibiting apoptosis and necroptosis. Nature 513: 90-4
  9. Welz PS, Wullaert A, Vlantis K, Kondylis V, Fernandez-Majada V, Ermolaeva M, Kirsch P, Sterner-Kock A, van Loo G, Pasparakis M (2011) FADD prevents RIP3-mediated epithelial cell necrosis and chronic intestinal inflammation. Nature 477: 330-4
  10. Nenci A, Becker C, Wullaert A, Gareus R, van Loo G, Danese S, Huth M, Nikolaev A, Neufert C, Madison B, Gumucio D, Neurath MF, Pasparakis M (2007) Epithelial NEMO links innate immunity to chronic intestinal inflammation. Nature 446: 557-61